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Melarsonyl

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names：
Melarsonyl
CAS號(hào)：
37526-80-0
MDL Number： No data available
MF(分子式)： C13H13AsN6O4S2 MW(分子量)： 456.33
EINECS:No data available Reaxys Number:No data available
Pubchem ID:25908 Brand:BIOFOUNT

Melarsonyl (37526-80-0,Melarsonic acid) 是一種驅(qū)蟲(chóng)劑，Melarsonyl 可有效抑制寄生蟲(chóng).

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000859-5mg	5mg	>95%	￥ 8100.00	￥ 8100.00		Backorder	- +	￥ 0.00
YZM000859-1mg	1mg	>95%	￥ 3900.00	￥ 3900.00		Backorder	- +	￥ 0.00

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中文別名	Melarsonyl(37526-80-0);Melarsonic acid;Melarsonylum (acid);UNII-OOO8QR9Y40
英文別名	Melarsonyl,37526-80-0
CAS號(hào)	37526-80-0
Inchi	InChI=1S/C13H13AsN6O4S2/c15-11-18-12(16)20-13(19-11)17-6-3-1-5(2-4-6)14-25-7(9(21)22)8(26-14)10(23)24/h1-4,7-8H,(H,21,22)(H,23,24)(H5,15,16,17,18,19,20)
InchiKey	LDILLULDEJXERI-UHFFFAOYSA-N
分子式 Formula	C13H13AsN6O4S2
分子量 Molecular Weight	456.33
溶解度Solubility
性狀	Solid
儲(chǔ)藏條件 Storage conditions	Store in a cool and dry place

Melarsonyl (37526-80-0,Melarsonic acid)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類(lèi)存儲(chǔ)，并交于專(zhuān)業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

Melarsonyl (37526-80-0,Melarsonic acid) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Melarsonyl (37526-80-0,Melarsonic acid),Melarsonyl 試劑,Melarsonyl 抑制劑,Melarsonyl 的純度,Melarsonyl的作用,Melarsonyl的合成,Melarsonyl的外觀,Melarsonyl的性質(zhì),Melarsonyl的含量,Melarsonyl的廠家,Melarsonyl 的生產(chǎn)

產(chǎn)品說(shuō)明	Melarsonyl (37526-80-0,Melarsonic acid) 是一種驅(qū)蟲(chóng)劑，Melarsonyl ???????可有效抑制寄生蟲(chóng).
Introduction	Melarsonyl (37526-80-0,Melarsonic acid) is an anthelmintic agent which can inhibitparasitepotently.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)

Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution
Abstract:Twelve new dithiaarsanes were evaluated for their in vitro and in vivo trypanocidal properties in regard to their three parent molecules, 4-amino-phenylarsenoxide, melarsenoxide, and 4-dansylamino-phenylarsenoxide. The most potent dithiaarsane, compound 2b, had a minimum effective concentration of 1.5 nM after 48 h of incubation and at a dose of 0.39 micromol/kg of body weight (0.2 mg/kg) administered subcutaneously cured 100% of mice acutely infected with Trypanosoma brucei brucei CMP. With this model, the chemotherapeutic index of compound 2b was 512, compared to 256 for melarsamine dihydrochloride (Cymelarsan) under the same conditions. With a chronic infection produced by T. brucei brucei GVR, compound 2b cured 100% of mice after treatment at a dose of 25 micromol/kg (12.5 mg/kg) for 4 consecutive days, whereas melarsamine dihydrochloride and potassium melarsonyl (Trimelarsan) cured less than 50% mice at this dose. For both acute and late-stage infections, dithiaarsanes having a melaminophenyl ring exhibited the most-potent trypanocidal activity. Compound 2b is thus one of the most active organoarsenicals described in a mouse trypanosomiasis model. Considering that the main intracellular targets of organoarsenicals are thiol groups, we studied the possibility of ligand exchange between Cymelarsan and several dithiols. In aqueous solution, we observed a rapid exchange of cysteamine from melarsamine with free cysteamine and also with various dithiols always in favor of more stable cyclic derivatives. These ligand exchanges suggest the ability of trivalent organoarsenicals to react with targets such as trypanothione and dihydrolipoic acid. Among several ligands, a 1,3-dimercaptopropane moiety appeared the most suitable for trypanocidal activity.

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