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番木瓜堿

NMR下載 COA and HPLC MSDS下載
names：
Carpaine
CAS號：
3463-92-1
MDL Number：
MF(分子式)： C28H50N2O4 MW(分子量)： 478.71
EINECS:222-414-2 Reaxys Number:
Pubchem ID:442630 Brand:BIOFOUNT

番木瓜堿(3463-92-1,Carpaine)是一種生物堿，是木瓜葉的主要成分，番木瓜堿已顯示出具有心血管作用和植物代謝產物的作用。番木瓜堿是生物堿和大環糖苷。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000832-5mg	5mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000832-1mg	1mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00

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中文別名	番木瓜堿(3463-92-1,Carpaine);番木瓜鹼
英文別名	Carpaine(3463-92-1);(+)-Carpaine
CAS號	3463-92-1
Inchi	InChI=1S/C28H50N2O4/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25/h21-26,29-30H,3-20H2,1-2H3/t21-,22-,23+,24+,25-,26-/m0/s1
InchiKey	AMSCMASJCYVAIF-QCVMBYIASA-N
分子式 Formula	C28H50N2O4
分子量 Molecular Weight	478.71
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	存放在陰涼干燥處，短期（數天至數周）在0-4℃，長期（數月至數年）在-20℃。

番木瓜堿(3463-92-1,Carpaine)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染

Carpaine(3463-92-1) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	番木瓜堿(3463-92-1,Carpaine)是一種有效的具有抗血小板減少活性的生物堿，在維持血小板數目方面表現出強烈的活性，無急性毒性。
Introduction	Carpaine (3463-92-1,番木瓜堿) is an effective alkaloid with anti-thrombocytopenic activity. It exhibits strong activity in maintaining the number of platelets without acute toxicity.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Anwendung der Massenspektrometrie zur Strukturaufkl?urung von Alkaloiden, 5. Mitt.: Die Struktur des Carpains(Monatshefte für Chemie und verwandte Teile anderer Wissenschaften,1964)

Carpaine: An alkaloid of Carica papaya—its chemistry and pharmacology(Economic Botany,1971)

Phytochemical examination of the leaves of carica papaya L.(Economic Botany,1956)

Five decades in the study of natural products(Journal of Chemical Sciences,2002)

Molecular docking studies of phytochemicals against trehalose–6–phosphate phosphatases of pathogenic microbes(Beni-Suef University Journal of Basic and Applied Sciences,2020)

Weak C-H…O hydrogen bonds in alkaloids: An overview
Abstract:An overview of general classification scheme, medicinal importance and crystal structure analysis with emphasis on the role of hydrogen bonding in some alkaloids is presented in this paper. The article is based on a general kind of survey while crystallographic analysis and role of hydrogen bonding are limited to only those alkaloids whose three-dimensional structure has been reported by us. The C-H…O hydrogen bonding in the solid state in alkaloids has been found to be predominant and this observation makes the role of hydrogen bonding in organic molecular assemblies very important.

Evaluation of anti-dengue activity of Carica papaya aqueous leaf extract and its role in platelet augmentation
Abstract:Dengue disease is characterized by a marked decrease in platelet count, which is life threatening. In the present study, we investigated the antiviral activity of an aqueous extract of Carica papaya leaves (PLE) against dengue virus (DENV) and its effect on platelet augmentation. The anti-dengue activity of PLE in DENV-infected THP-1 cells was examined by immunoblotting and flow cytometry. The effect of PLE on erythrocyte damage was investigated using hemolytic and anti-hemolytic assays. Virus-infected THP-1 cells were assayed for IFN-α secretion. The effect of PLE on platelet augmentation in rats with cyclophosphamide-induced thrombocytopenia was also investigated. The platelet count of blood from the retro-orbital plexus of rats was determined on the 1st, 4th, 7th, 11th and 14th day of study. On the 14th day, the rats were sacrificed for histopathological examination of the liver, kidney and spleen. Plasma of thrombocytopenic rats was tested for thrombopoietin (TPO) and IL-6 secretion. The data suggest that PLE significantly decreases the expression of the envelope and NS1 proteins in DENV-infected THP-1 cells. A marked decrease in intracellular viral load upon PLE treatment confirmed its antiviral activity. This also resulted in a significant decrease in erythrocyte damage and hydrogen-peroxide-induced lipid peroxidation. A significant increase in the number of platelets was found in thrombocytopenic rats treated with PLE, along with an increase in IL-6 and TPO levels. These findings suggest that PLE can potentially be used as an antiviral agent, as it helps in platelet augmentation and exhibits antiviral activity against DENV.

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