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甘草黃酮B

NMR下載 COA and HPLC MSDS下載
names：
Licoflavone B
CAS號：
91433-17-9
MDL Number：
MF(分子式)： C25H26O4 MW(分子量)： 390.47
EINECS: Reaxys Number:
Pubchem ID:11349817 Brand:BIOFOUNT

甘草黃酮B(91433-17-9,Licoflavone B)是一種從黃草甘草中分離出來的類黃酮，甘草黃酮B可以抑制血吸蟲的活性。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000828-5mg	5mg	>95%	￥ 3402.00	￥ 3402.00		Backorder	- +	￥ 0.00
YZM000828-1mg	1mg	>95%	￥ 1092.00	￥ 1092.00		Backorder	- +	￥ 0.00

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中文別名	甘草黃酮B(91433-17-9,Licoflavone B)
英文別名	Licoflavone B(91433-17-9);Prenyllicoflavone A
CAS號	91433-17-9
Inchi	InChI=1S/C25H26O4/c1-15(2)5-7-17-11-19(9-10-21(17)26)24-14-23(28)20-12-18(8-6-16(3)4)22(27)13-25(20)29-24/h5-6,9-14,26-27H,7-8H2,1-4H3
InchiKey	GLDVIKFETPAZNV-UHFFFAOYSA-N
分子式 Formula	C25H26O4
分子量 Molecular Weight	390.47
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	存放在陰涼干燥處，短期（數天至數周）在0-4℃，長期（數月至數年）在-20℃。

甘草黃酮B(91433-17-9,Licoflavone B)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染

Licoflavone B(91433-17-9) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	甘草黃酮B(91433-17-9,Licoflavone B)是一種從黃草甘草中分離出來的類黃酮，甘草黃酮B可以抑制血吸蟲的活性。
Introduction	Licoflavone B (91433-17-9, 甘草黃酮B) is a flavonoid isolated from yellow licorice root. Licorice flavone B can inhibit the activity of schistosomes.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Pharmacological Activities and Phytochemical Constituents(Liquorice,2017)

Synthesis of 6,7-Dibromoflavone and Its Regioselective Diversification via Suzuki–Miyaura Reactions(Synthesis,2017)

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae) PMID 32106571; Biomolecules 2020 Feb; 10(3): (Review Article)

Chemical studies of Chinese licorice-roots. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang PMID 8069956; Chemical & pharmaceutical bull

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae) PMID 26454044; Experimental parasitology 2015 Dec; 159(?):207-14

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae)
Abstract:Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs. In this work, the in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots (GI) and its isolated compounds echinatin, licoflavone A and licoflavone B were evaluated against S. mansoni adult worms. Results showed that GI (200 μg/mL) was active against adult schistosomes, causing 100% mortality after 24 h of incubation. Chromatographic fractionation of GI led to isolation of echinatin, licoflavone A and licoflavone B. Licoflavone B (25-100 μM) caused 100% mortality, tegumental alterations, and reduction of oviposition and motor activity of all adult worms, without affecting mammalian Vero cells. Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S. mansoni worms in a dose-dependent manner after incubation with licoflavone B. Licoflavone B also showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. Docking studies predicted different interactions between licoflavone B and S. mansoni ATPDase 1, corroborating with the in vitro inhibitory activity. This report demonstrated the first evidence for the schistosomicidal activity of licoflavone B and suggests that its mechanism of action involve the inhibition of S. mansoni ATP diphosphohydrolases.

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