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HSV-TK底物

NMR下載 COA and HPLC MSDS下載
names：
HSV-TK substrate
CAS號：
111687-37-7
MDL Number：
MF(分子式)： C11H15N5O4 MW(分子量)： 281.27
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物，并在表達HSV-T K和旁觀者細胞中誘導多對數細胞毒性，具有抗腫瘤活性。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000723-250mg	250mg		￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000723-100mg	100mg	>97%	￥ 0.00	￥ 0.00		2-3天	- +	￥ 0.00

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中文別名	HSV-TK底物(111687-37-7);2-氨基-9-[（（1R，2S，3R，4R）-2,3-二羥基-4-（羥甲基）環戊基] -1,9-二氫-6H-嘌呤-6-; D-碳環-2'-脫氧鳥苷;
英文別名	HSV-TK substrate(111687-37-7);HSV-TK SUBSTRATE;(1R,2S,3R,4R)-2-Amino-9-(2,3-dihydroxy-4-hydroxymethylcyclopentyl)-1,9-dihydropurin-6-one; 2-amino-9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-1H-purin-6(9H)-one; 2-amino-9-(2,3-dihydroxy-4-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one; 2-Amino-9-((1R,2S,3R,4R)-2,3-dihydroxy-4-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one; 6H-Purin-6-one, 2-amino-9-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, [1R-(1α,2β,3β,4α)]-; 2-Amino-9-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-6H-purin-6-one; D-Carbocyclic-2'-deoxyguanosine;
CAS號	111687-37-7
Inchi	No data available
InchiKey	No data available
分子式 Formula	C11H15N5O4
分子量 Molecular Weight	281.27
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據產品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

HSV-TK底物(111687-37-7,HSV-TK substrate)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：HSV-TK底物試劑,HSV-TK底物雜質,HSV-TK底物中間體,HSV-TK底物密度,HSV-TK底物溶解度,HSV-TK底物旋光度,HSV-TK底物合成,HSV-TK底物閃點,HSV-TK底物熔點,HSV-TK底物MSDS,

產品說明	HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物,并在表達HSV-TK和旁觀的細胞中誘導多對數細胞毒性.
Introduction	HSV-TK底物(111687-37-7,HSV-TK substrate)is a substrate for HSVK, and induces multiog cytotoxicity in HSVKxpressing and bystander cells. HSVK substrate shows antitumor activity.
Application1	HSV-TK底物顯示抗腫瘤活性。
Application2
Application3

HSV-TK底物(111687-37-7,HSV-TK substrate)藥理學：

HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物,并在表達HSV-TK和旁觀的細胞中誘導多對數細胞毒性.HSV-TK底物顯示抗腫瘤活性。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Shewach DS, et al. Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells. Hum Gene Ther. 2002 Mar 1;13(4):543-51.

HSV-TK底物(111687-37-7,HSV-TK substrate)參考文獻：

1、Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells
Donna S Shewach 1, Patrick J Murphy, Blaine W Robinson, Jennifer Vuletich, Paul D Boucher, Anna L Blobaum, Laura Zerbe, John A Secrist 3rd, William B Parker

Abstract Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing as well as nonexpressing bystander cells. We now report that another substrate for HSV-TK, D-carbocyclic 2'-deoxyguanosine (CdG), induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells at concentrations <or=3 microM. We have compared the cytotoxicity and cell cycle effects of CdG to that observed with GCV in two human tumor cell lines. The results demonstrated that cytotoxicity of CdG was similar to that of GCV in both U251 glioblastoma and SW620 colon carcinoma cells that stably expressed HSV-TK. In addition, CdG induced a potent bystander effect in both cell types in co-cultures consisting of HSV-TK-expressing and nonexpressing bystander (lacZ-expressing) cells at ratios of 50:50 or 10:90. Selectivity for HSV-TK-expressing compared to lacZ-expressing cells was similar for CdG and GCV in the U251 cells, however CdG was less selective than GCV in the SW620 cell lines. Despite their ability to induce multi-log cytotoxicity at similar concentrations, CdG and GCV exhibited differential effects on cell cycle progression. Cells incubated with 1 microM CdG for 24 hr accumulated in S-phase and G(2)/M after drug washout, and the majority of cells died prior to cell division. This contrasts with the delayed effects of 1 microM GCV that were not evident until after cell division when cells attempted S-phase for the second time. Thus, CdG is a potent cytotoxic agent that merits further investigation to determine whether it will be therapeutically effective in enzyme-prodrug therapy with HSV-TK.

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