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曲金剛胺

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names：
Tromantadine
CAS號：
53783-83-8
MDL Number： MFCD00869480
MF(分子式)： C16H28N2O2 MW(分子量)： 280.41
EINECS:258-770-0 Reaxys Number:
Pubchem ID:64377 Brand:BIOFOUNT

曲金剛胺(53783-83-8,Tromantadine)是Amantadine衍生物，具有抗皰疹活性，曲金剛胺可抑制單純皰疹病毒1型（HSV-1）和HSV-2的復制。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000720-5mg	5mg	>99.0%	￥ 5062.00	￥ 5062.00		Backorder	- +	￥ 0.00
YZM000720-1mg	1mg	>99.0%	￥ 1950.00	￥ 1950.00		2-3天	- +	￥ 0.00

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中文別名	曲金剛胺(53783-83-8);D 41;曲曼他定;N-（1-金剛烷基）-2-（2-二甲基氨基乙氧基）乙酰胺;姜黃素;曲曼他定'鹽酸金剛烷胺;一水合鹽酸金剛烷胺，一水合物;甘露定;維魯·梅爾茲;維魯·梅爾茲·塞羅爾;塞魯爾;
英文別名	Tromantadine(53783-83-8);D 41;N-(1-adamantyl)-2-(2-dimethylaminoethoxy)acetamide;tromantadin;tromantadine;tromantadine monohydrochloride;tromantadine monohydrochloride, monohydrate;tromantidine;Viru-Merz;Viru-Merz serol;Viru-Serol;
CAS號	53783-83-8
Inchi	InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)
InchiKey	UXQDWARBDDDTKG-UHFFFAOYSA-N
分子式 Formula	C16H28N2O2
分子量 Molecular Weight	280.41
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	存放在陰涼干燥處Pure form -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

曲金剛胺(53783-83-8,Tromantadine)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	曲金剛胺(53783-83-8,Tromantadine)是一種有效的單純皰疹病毒 (HSV) 的抑制劑
Introduction	曲金剛胺(53783-83-8,Tromantadine) is a herpes simplex virus (HSV) inhibitor.
Application1	曲金剛胺是具有抗皰疹活性的金剛烷胺衍生物，可抑制單純皰疹病毒1型（HSV-1）和HSV-2復制
Application2	Tromantadine是一種局部抗皰疹藥物，對單純皰疹病毒1型（HSV-1）復制具有兩個獨立的作用：早期，在病毒結合或穿透過程中，晚期，在DNA合成開始后。
Application3

曲金剛胺(53783-83-8,Tromantadine)藥理學：

1、曲金剛胺是一種環狀胺，具有抗單純皰疹病毒的活性。Tromantadine抑制病毒體吸收到細胞表面，以及病毒的滲透和脫膜。 Tromantadine在捷克共和國的市場名為Viru-Merz。曲金剛胺是一種抗病毒藥，用于治療帶狀皰疹和單純性皰疹。

2、曲金剛胺是抗病毒劑，曲金剛胺用于預防或治療病毒性疾病的藥物。曲金剛胺可能發揮作用的方式包括通過抑制病毒DNA聚合酶來防止病毒復制。曲金剛胺與特定的細胞表面受體結合并抑制病毒滲透或脫殼；抑制病毒蛋白質合成；或阻止病毒組裝的后期。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.

Cheetham JJ, et al. Comparison of the interaction of the anti-viral chemotherapeutic agents amantadine and tromantadine with model phospholipid membranes. Biosci Rep. 1987 Mar;7(3):225-30.

Comparison of the interaction of the anti-viral chemotherapeutic agents amantadine and tromantadine with model phospholipid membranes Bioscience Reports 1987

Tromantadine Reactions Weekly 2018

Aciclovir and tromantadine have comparable efficacy InPharma 1989

曲金剛胺(53783-83-8,Tromantadine)參考文獻：

1.Separation methods for tricyclic antiviral drugs.
Suckow RF1. J Chromatogr B Biomed Sci Appl. 2001 Nov 25;764(1-2):313-25.

A review of the published analytical methodology for the tricyclic antiviral (TAV) drugs is presented. While amantadine and rimantadine are the only two approved drugs for the prophylaxis and treatment of the influenza A virus, amantadine has also been approved for the treatment of Parkinson's disease. In addition, a few structurally related compounds are finding important clinical applications in other central nervous system-related disorders. To effectively evaluate the pharmacokinetics, biotransformations, stability, and other critical parameters that are necessary for pre-clinical and clinical studies, analytical methodology that conforms to the rigors of regulatory requirements must be developed and made available. This review discusses the analytical methods used in the determination of amantadine, rimantadine, tromantadine and memantine and the pre-clinical and clinical application of these techniques.

2.Topical tromantadine in the treatment of genital herpes. A double-blind placebo controlled study.
Petersen CS1, Weismann K, Avnstorp C, Rasmussen LP, Fogh H, Tikjøb G. Dan Med Bull. 1993 Sep;40(4):506-7.

A randomised double-blind placebo controlled trial was performed to assess the efficacy and safety of tromantadine ointment 1% in male patients with genital herpes. 45 patients with penile genital herpes of less than three days duration were randomised to local treatment with tromantadine ointment 1% or placebo (ointment base alone) five times daily up to 12 days. No difference in time of healing could be detected between the two groups (p = 1.0). Both the objective signs (vesicles, pustules, ulceration, and glandular swelling) and the subjective symptoms (itching, burning, pain and dysuria) all diminished simultaneously in the two groups.

3.Allergic contact dermatitis from tromantadine.
Jáuregui I1, Urrutia I, Gamboa PM, Antépara I. J Investig Allergol Clin Immunol. 1997 Jul-Aug;7(4):260-1.

Tromantadine is a topical antiviral agent derived from amantadine. In previous reports, 5% of treated patients developed contact allergy. We report the case of a 28-year-old woman who had a sudden worsening of a lip herpes after treatment with a tromantadine ointment, with strong positive patch testing to this substance. The purpose of this paper is to call attention to the fact that tromantadine is still widely used in several European countries as a second-line therapy for lip herpes, and therefore, new cases of sensitization to tromantadine are likely to occur.

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