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KMUP-3

NMR下載 COA and HPLC MSDS下載
names：
1,3-dimethyl-7-(2-(4-(4-nitrophenyl)piperazin-1-yl)ethyl)-3,7-dihydro-1H-purine-2,6-dione
CAS號：
421556-16-3
MDL Number：
MF(分子式)： C19H23N7O4 MW(分子量)： 413.43
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	KMUP-3
英文別名	KMUP-3; KMUP 3; KMUP3;
CAS號	421556-16-3
Inchi	InChI=1S/C19H23N7O4/c1-21-17-16(18(27)22(2)19(21)28)25(13-20-17)12-9-23-7-10-24(11-8-23)14-3-5-15(6-4-14)26(29)30/h3-6,13H,7-12H2,1-2H3
InchiKey	WUNWRZDRKZFAHV-UHFFFAOYSA-N
分子式 Formula	C19H23N7O4
分子量 Molecular Weight	413.43
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	KMUP-3(CAS:421556-16-3):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	KMUP-3 is an enhancer of cGMP activity. It also acts as an aortic smooth muscle relaxant.
Application1
Application2
Application3

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危險性	Warning
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[1]Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization. Kaohsiung J Med Sci. 2016 Feb;32(2):55-67. doi: 10.1016/j.kjms.2016.01.005. Epub 2016 Feb 24. PubMed PMID: 26944323.

[2]Winardi W, Wang CJ, Lin CL, Wu SC, Tsai HP, Kuo YH, Lee MY, Chen IJ, Kwan AL. Attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage by the bronchodilator KMUP-3. Acta Neurochir Suppl. 2013;11

5:239-46. doi: 10.1007/978-3-7091-1192-5_43. PubMed PMID: 22890675.

[4]Liu CP, Yeh JL, Wu BN, Chai CY, Chen IJ, Lai WT. KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance. Br J Pharmacol. 2011 Jan;162(1):126-35. doi: 10.1111/j.1476-5381.2010.01024.x. PubMed PMID: 20840538; PubMed Central PMCID: PMC3012411.

[5] Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G. Mol Pharmacol. 2006 Sep;70(3):977-85. Epub 2006 Jun 5. PubMed PMID: 16754782.

5: Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ. A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G. J Pharmacol Exp Ther. 2006 Feb;316(2):709-17. Epub 2005 Oct 18. PubMed PMID: 16234412.

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